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Tulynode Biosciences Inc · San Diego, California
Company Description
Tulynode Biosciences Inc. is a biotechnology company dedicated to addressing critical unmet needs in oncology by harnessing each patient’s own immune system. The company focuses on activating autologous immune cells that are specific to an individual’s tumor, aiming to deliver effective and safer cellular therapies with ex vivo manipulation. Tulynode’s gene modification strategy and “Immuno-Pod” platform is designed to expose otherwise inaccessible tumors in vivo, enhancing tumor-specific immune cell activation. This approach seamlessly integrates ex vivo and in vivo processes to create highly personalized, next-generation cancer treatments. Team members have the opportunity to contribute to innovative therapies at the intersection of immunology, gene modification, and oncology.
Role Description
We are seeking a highly motivated and detail-oriented
Senior Research Associate/Scientist
to join our Discovery and Cell Therapy team. This hands-on, laboratory-based role focuses on utilizing
lentiviral vector platforms
to genetically engineer
tumor-infiltrating lymphocytes (TILs)
for next-generation adoptive cell therapies. The successful candidate will support molecular cloning, lentivirus production, T-cell transduction, and the functional characterization of engineered immune cells. This position is ideal for a MS/BS-level scientist with strong foundational skills in molecular biology and a passion for cancer immunotherapy related to T cell therapy
Key
Lentiviral Vector Production & Engineering:
Design and execute protocols for producing, concentrating, and titering lentiviral vectors. Assist in the construction of transfer and packaging plasmids for viral delivery.
TIL Cultivation & Modification:
Isolate, expand, and maintain primary human T cells and tumor-infiltrating lymphocytes (TILs) using aseptic tissue culture techniques. Execute and optimize lentiviral transduction workflows to introduce genetic modifications.
Molecular Biology Support:
Perform routine molecular biology techniques, including plasmid cloning, genomic DNA/RNA isolation, qPCR/RT-qPCR, and Sanger sequencing analysis.
Phenotypic & Functional Characterization:
Perform multi-color
flow cytometry
(FACS) to assess T-cell immunophenotyping, transduction efficiency, and surface marker expression. Run in vitro functional assays, including cytotoxicity (tumor cell killing) and cytokine production profiling (ELISA/Luminex).
Data Management & Collaboration:
Maintain meticulous electronic laboratory notebooks (ELN), analyze datasets using software like FlowJo and GraphPad Prism, and present findings to cross-functional teams.
Qualifications
1–3+ years of post-graduation laboratory experience preferably in a biotechnology industry setting (title commensurate with experience).
o Demonstrated proficiency in
aseptic mammalian cell culture
, ideally with primary human immune cells (T cells) or TILs.
o Hands-on experience with
transfection methods
(e.g., HEK293T packaging) and
lentiviral transduction workflows
.
o Foundational molecular biology skills (PCR, restriction cloning, or Gibson Assembly).
· Experience with multi-color flow cytometry panels and data analysis using FlowJo.
Details
| Company | Tulynode Biosciences Inc |
| Location | San Diego, California |
| Type | FULL TIME |
| Niche | Science and engineering professionals |