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Constructive Bio · Balsham, England, United Kingdom
Constructive Bio is a growing Cambridge based biotechnology company built on a simple conviction: the molecules that matter most are often the ones that can’t yet be made.
We’ve rewritten the genetic code to give cells access to new ncAA chemical building blocks - expanding the space of proteins that can be designed, engineered, and manufactured. Our platform moves from unexplored molecular territory to industrial-scale production, turning scientific possibility into manufacturable reality.
From next-generation medicines to advanced materials, Constructive shifts the question from “can we make this?” to “what should we make next?”
We’re proud to be a spinout from Professor Jason Chin's laboratory at the MRC Laboratory of Molecular Biology in Cambridge. You can learn more about the Chin lab achievements here.
Since launching in 2022, Constructive Bio has raised $73 million in venture capital, including a $15 million seed round and a $58 million Series A, to commercialise our breakthrough synthetic genomics platform. Today, we are advancing a growing pipeline of programmes based on world-leading science, enabling the precise engineering of biology to create transformative medicines, materials and sustainable products.
As a fast-growing biotech at the forefront of generative biology, we're building a team of exceptional people who share our ambition to redefine what's possible with biology.
The Scientist, Synthetic Genomics will design and execute experimental strategies
that support the development of our proprietary technologies for genome synthesis and large DNA assembly, with a focus on the creation of synthetic microorganisms with reprogrammed genetic codes that enable the recombinant production of valuable proteins and peptides containing multiple different non-canonical monomers. The role contributes to our platform through robust experimental design, thorough documentation, problem-solving, and collaboration with scientists, engineers and bioinformaticians. The ideal candidate will have a background in biological engineering and a proven track record of designing, executing and documenting experiments. The post holder will have the opportunity to make a significant impact on the next stage of our platform development.
This role is open at either Scientist or Senior Scientist level. We will determine the level at offer stage based on depth of experience, scope of independent ownership, and leadership contribution.
Deploy and develop our proprietary genome synthesis platform for the construction of microorganisms controlled by computationally designed, chemically synthesized genomes
Independently conceive and execute experimental strategies for optimizing the growth and production phenotypes of strains with reprogrammed genetic codes
Stay up to date with cutting-edge technologies in DNA synthesis, DNA assembly and large-scale genome engineering
Record, analyse and interpret data, and regularly communicate progress, results and challenges to the wider R&D and leadership teams
Collaborate closely with experimental and computational colleagues to deliver results on time and in line with the company's objectives
About you
PhD or equivalent experience in molecular biology, microbiology, biochemistry, bioengineering or a related field
Proficiency in the design and execution of DNA cloning, including Gibson, Golden Gate assembly or similar
An engineering mindset, and experience in designing, building and troubleshooting genetic systems for target outputs
Experience analysing and interpreting next-generation sequencing data, particularly Illumina and/or Oxford Nanopore
Familiarity with techniques for DNA manipulation in prokaryotes, such as base editing, homologous recombination, conjugation, transduction and transposition
Strong problem-solving skills and the ability to work independently in a collaborative environment with shifting priorities
Good working knowledge of bacterial genetics, genome annotation tools and genomic databases
Familiarity with in vivo DNA assembly workflows in E. coli, Saccharomyces cerevisiae or other microorganisms
Familiarity with laboratory automation equipment and high-throughput molecular biology workflows
Familiarity with Benchling or a comparable ELN
Other details
Laboratory-based at our site in Whittlesford, South Cambridgeshire
Competitive salary
25 days holiday plus bank holidays
Company pension (matching up to 8%), life assurance, private medical insurance and group income protection schemes
Opportunity to be part of our employee long term incentive scheme
Newly fitted, purpose-built facilities in Whittlesford, South Cambridge, with on-site parking and excellent rail links to Cambridge, London and Norwich
A collaborative and pioneering environment at the cutting edge of synthetic genomics and engineered translation
Please note that our office space is dog friendly.
We are committed to building a culture founded on trust, respect and collaboration, where curiosity, openness and scientific excellence thrive.
We imagine: We think big and plan our own path for success.
We pioneer: We take action and grow together as one to break moulds.
We deliver: We take ownership and work together to deliver excellence.
Constructive Bio is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
Details
| Company | Constructive Bio |
| Location | Balsham, England, United Kingdom |
| Type | FULL TIME |
| Niche | tech |